Lehigh University - ECE: Chao Zhou

Chao Zhou, PhD

Assistant Professor of Electrical & Computer Engineering

Assistant Professor of Bioengineering

Ph.D. Physics, University of Pennsylvania 2007
M.S. Physics, University of Pennsylvania 2003
B.S. Physics, Peking University 2001
(Curriculum Vitae)

Started at Lehigh in June 2012

Contact Information:
Office: Packard Laboratory Room 402

19 Memorial Drive West

Bethlehem, PA 18015

Tel: 610-758-5092

Lab: 610-758-0201

E-mail: chaozhou(at)lehigh(dot)edu
ResearcherID: http://www.researcherid.com/rid/A-1327-2007

Research Interests:

I am interested in developing novel optical imaging technologies for biomedical applications. Particularly, he is interested in developing optical coherence tomography (OCT) and microscopy (OCM) technologies to perform “optical biopsy” and generate 3D in situ images of tissue morphology, function and pathological status in real-time without the need to remove and process specimens. He is also interested in applying these technologies to a variety biological and clinical applications, including cancer research, neuroscience, developmental biology and tissue engineering. Currently, his group is working on developing methodologies to enable molecular-contrast for OCT and OCM, to extract 3D cerebral hemodynamic information of animal brains, and to evaluate functional development of embryonic hearts of fruit flies and zebrafish.

For more details, Click Here!

Keywords: Biomedical Optics, Optical Coherence Tomography (OCT), Optical Coherence Microscopy (OCM), Diffuse Optical Spectroscopy/Imaging, Laser Speckle Imaging, Cancer Imaging, Developmental Biology

Positions and Employments

06/2012 - Assistant Professor

Department of Electrical and Computer Engineering and Bioengineering Program

Lehigh University, PA, USA

08/2007 - Postdoctoral Associate with Prof. James G. Fujimoto

5/2012 Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics

Massachusetts Institute of Technology, Cambridge, MA, USA

05/2002 - Research Assistant with Prof. Arjun G. Yodh

08/2007 Department of Physics and Astronomy

University of Pennsylvania, Philadelphia, PA, USA

Awards and Honors

2011 Pathway to Independence Award, National Institutes of Health (NIBIB)

2007 Young Bursary winner for Brain07 Conference, International Society for Cerebral Blood Flow and Metabolism (ISCBFM)

2007 Organization for Human Brain Mapping (OHBM) Travel Award

2004, 2006 GSAC Travel Award, University of Pennsylvania

2004 Student Travel grant for Optical Society of America topical meeting

2000 Third Class Prize in the 8th Challenge Cup of Extracurricular Scientific and Technological Works Competition, Peking University

1998 Young Eagle Scholarship for Outstanding Academic Performance in the Honor Science Program, Peking University

1998 PanDeng Scholarship for Undergraduate Research, Chinese Academy of Sciences and Peking University

1997 Outstanding Freshmen Scholarship, Peking University

1996 Second Class Prize in the 13th Chinese Physics Olympiad, Chinese Physical Society

Grant Support

“Integrated Optical Coherence Tomography and Microscopy for Molecular-Targeted Imaging,” 06/2011-05/2014, National Institutes of Health (NIBIB, K99/R00 Pathway to Independence Award), Principal Investigator

Selected Publications (from over 40 peer-reviewed publications, >900 citations, h-index: 18)

T.-H. Tsai, C. Zhou, Y.K. Tao, H.-C. Lee, O.O. Ahsen, M. Figueiredo, T. Kirtane, D.C. Adler, J. Schmitt, Q. Huang, J.G. Fujimoto, and H. Mashimo. Structural Markers Observed with Endoscopic Three-dimensional Optical Coherence Tomography Correlating with Barrett's Esophagus Radiofrequency Ablation Treatment Response. Gastrointest. Endosc., 76(6):1104-1112, 2012.
C. Zhou, T. Kirtane, T.-H. Tsai, H.-C. Lee, D.C. Adler, J. Schmitt, Q. Huang, J.G. Fujimoto, and H. Mashimo. Three-Dimensional Endoscopic Optical Coherence Tomography Imaging of Cervical Inlet Patch. Gastrointest. Endosc., 75(3), 675-677, 2012.
C. Zhou, T.-H. Tsai, H.-C. Lee, T. Kirtane, M. Figueiredo, Y.K. Tao, O.O. Ahsen, D.C. Adler, J. Schmitt, Q. Huang, J.G. Fujimoto, and H. Mashimo. Characterization of Buried Glands Pre- and Post-Radiofrequency Ablation using Three-dimensional Optical Coherence Tomography. Gastrointest. Endosc., 76(1):32-40, 2012.
A. Li, C. Zhou, J. Moore, P. Zhang, T.-H. Tsai, H.-C. Lee, D.M. Romano, M.L. McKee, D.A. Schoenfeld, M.J. Serra, K. Raygor, H.F. Cantiello, J.G. Fujimoto, and R.E. Tanzi. Changes in the Expression of the Alzheimer’s Disease-Associated Presenilin Gene in Drosophila Heart Leads to Cardiac Dysfunction. Curr. Alzheimer Res., 8(3):313-322, 2011.
C. Zhou, D.W. Cohen, Y. Wang, H.-C. Lee, A. Mondelblatt, T.-H. Tsai, A.D. Aguirre, J.G. Fujimoto, and J.L. Connolly. Integrated Optical Coherence Tomography and Microscopy for Ex Vivo Multiscale Evaluation of Human Breast Tissues. Cancer Res., 70(24):10071-10079, 2010.
C. Zhou, T.-H. Tsai, D.C. Adler, H-C. Lee, D.W. Cohen, A. Mondelblatt, Y.H. Wang, J.L. Connolly and J.G. Fujimoto. Photothermal Optical Coherence Tomography (OCT) in ex vivo Human Breast Tissues Using Gold Nanoshells. Opt. Lett., 35(5):700-702, 2010.
C. Zhou, Y.H. Wang, A.D. Aguirre, T.-H. Tsai, J.L. Connolly, and J.G. Fujimoto. Ex vivo Imaging of Human Thyroid Pathology Using Integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM). J. Biomed. Opt., 15(1):016001, 2010.
C. Zhou, S.A. Eucker, T. Durduran, G.Q. Yu, J. Ralston, S.H. Friess, R.N. Ichord, S.S. Margulies, and A.G. Yodh. Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury. J. Biomed. Opt., 14 (3):034015, 2009.
C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D.Y. Kimberg, G.Q. Yu, X.H. Chen, J.A. Detre, A.G. Yodh, and J.H. Greenberg. Acute functional recovery of cerebral blood ﬂow following forebrain ischemia in the rat. J. Cereb. Blood Flow Metab., 28(7):1275-1284, 2008.
C. Zhou, R. Choe, N. Shah, T. Durduran, G.Q. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B.J. Tromberg, and A.G. Yodh. Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy. J. Biomed. Opt., 12(5):051903, 2007.
C. Zhou, G.Q. Yu, D. Furuya, J.H. Greenberg, A.G. Yodh, and T. Durduran. Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain. Opt. Express, 14(3):1125-1144, 2006.

©2002-2006 P.C. Rossin College of Engineering & Applied Science
Packard Laboratory, Lehigh University, Bethlehem PA 18015